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Description
Background Glucagon-like peptide-1 (GLP-1) induces diuresis and natriuresis

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Clinical Significance: The 2025 updates reaffirm that while HbA1c remains central, a one-number-fits-all strategy is outdated

If your BMI falls below the threshold for compounded GLP-1, you may still be a candidate for our Microdosing program, a lower dose protocol built for patients seeking the metabolic, appetite, and longevity benefits of GLP-1 therapy at a gentler entry point

Outcomes included changes in left ventricular ejection fraction (LVEF), end-diastolic volume (LVEDV), end-systolic volume (LVESV), global longitudinal strain (GLS), left ventricular mass, left atrial volume (LAV), and NT-proBNP levels

This article reviews the efficacy and safety of different strategies to initiate and intensify basal insulin, with focus on new fixed ratio combinations of basal insulin with GLP-1 RAs available for use in a single injection pen (insulin degludec/liraglutide and insulin glargine/lixisenatide).
