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Table 9 Systemic complications in PDM

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In the brain, major GLP-1R-positive regions include the area postrema, ARC, VMH, and the ventrolateral medulla with lower expression in the PVH and NTS [395,396]

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The main mechanism underlying this phenomenon is the loss of the suppressive activity of insulin to regulate lipolysis in a metabolic dysregulated visceral adipose tissue, even during times of nutrient excess [17]