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There are also motility alterations, such as diarrhea explained by the rapid colonic transit, as GLP1 activates intrinsic afferent neurons containing calcitonin gene-related peptide that favors the frequency of peristaltic contractions (158) or constipation due to mechanisms dependent on nitric oxide and AMPc/PKA that reduces colon contractility (159)

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Properly treated hypothyroidism should not significantly limit tirzepatide effectiveness

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FDA Approves First Treatment for Patients with Liver Scarring Due to Fatty Liver Disease