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AGEs also affect keratinocytes and melanocytes, leading to the thinning of the stratum corneum and to the increased production of melanin

| Pros and Cons | Is it legit

A clinical trial that just began dosing patients at Johns Hopkins is testing something the diabetes world has suspected for years: that the same class of drugs millions of people take to manage blood sugar may be quietly protecting the brain from shrinking

Concerns Regarding Fluid Retention and Arrhythmic Risk One important concern regarding the use of GLP-1RAs in patients with HFrEF is the risk of fluid retention, as highlighted in a study involving liraglutide

The logic is that youre targeting neural mechanisms rather than dramatic weight loss, so you might avoid many of the risks associated with the higher doses while still getting some of the anti-inflammatory and pain-modulating effects

Taking into account the presence of ascending and descending projections between the brainstem and hypothalamus (as discussed earlier), it is possible that there is communication between these areas with regard to PYY 3-36 action