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Pre-treatment with a GLP1 receptor-blocking antibody neutralised the CNO-dependent improvement in glucose tolerance but did not affect the reduction in food intake, and an independent group of animals pair-fed to the CNO-treatment group demonstrated attenuated weight loss
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Immunofluorescence, Western blot, and RT-qPCR were used in the study
Understanding hypoglycemia risk and prevention strategies is essential for safe weight loss therapy
