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Mol Neurobiol (2018) 55(5):403050

Research consistently shows that starting at the lowest dose (0.25 mg) and increasing only every four weeks exactly as prescribed minimizes GI disruption
The study was supported in part by the Tyson Endowed Chair in Food Policy Economics

Tirzepatide controls blood sugar by stimulating insulin release, lowering glucagon levels and regulating appetite and energy metabolism for weight management

Cummings: There are a lot of hints that the drugs may act in the reward centers of the brain, and those actions may have something to do with why they seem to be associated with lower alcohol and substance abuse and smoking, and other compulsive behaviors like gambling and shopping
