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In findings from the Semaglutide Cardiovascular Outcomes Trial (SOUL) recently published in the New England Journal of Medicine , investigators reported that the use of oral semaglutide was associated with a significantly lower risk of major adverse cardiovascular events than a placebo, without an increase in the incidence of serious adverse events, in people with type 2 diabetes and atherosclerotic cardiovascular disease, chronic kidney disease, or both

Calorie expenditure stayed much closer to normal, even during calorie restriction

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Insulin resistance is the inadequate response of target tissues to the physiological effects of circulating insulin, such as decreased glucose uptake in skeletal muscles under insulin stimulation, inhibition of hepatic gluconeogenesis by insulin, and relief of the inhibitory effect of insulin on lipid breakdown in adipose tissue (Schenk et al., 2008)

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