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Orforglipron: a comprehensive review of an oral small-molecule GLP-1 receptor agonist for obesity and type 2 diabetes

2.3%) and there was no difference in the percentage of participants with acute pancreatitis or malignant neoplasms between the two groups [110]

AGEs receptor (RAGE) is expressed in human osteoclasts and stimulates the activation of nuclear factor Kappa-B in osteoclasts, thereby increasing the production of cytokines and reactive oxygen species

However, despite the anti-diabetic and anti-obesity functions, of these dual and triple agonists, the long-term safety, cardiovascular, and renal benefits of these multi-target therapies need further validation

Weight loss continues at the lower dose, albeit at a slower rate, and the metabolic health improvements accumulated during the higher-dose phase persist as long as the protocol continues