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As large-scale trials like EVOKE and EVOKE + unfold, integrating insights from estrogen biology could enhance the impact of GLP-1based therapies in neurodegenerative disease

Physiological factors affecting drug toxicity

, Southan, C

The problem is that this system can become dysregulated

Bloomfield DM, Krishna R, Hreniuk D, Hickey L, Ghosh K, Bergman AJ, Miller J, Gutierrez MJ, Stoltz R, Gottesdiener KM, et al: A thorough QTc study to assess the effect of sitagliptin, a DPP4 inhibitor, on ventricular repolarization in healthy subjects

In patients who are not tolerant to Metformin, GLP-1 drugs can be prescribed as an alternative from the start