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Common side effects: Headache Upper respiratory infection symptoms (sore throat, runny/stuffy nose) Constipation Vomiting Mouth ulcers Rare but serious side effects: Heart failure (shortness of breath, swelling, sudden weight gain) Pancreatitis (persistent nausea/vomiting, severe abdominal or back pain) Allergic reactions (hives, facial swelling, difficulty breathing) Hypoglycemia when combined with insulin or sulfonylureas (hunger, sweating, confusion) Kidney problems (decreased function or failure requiring dialysis) Severe skin reactions (blisters, skin erosion) Severe joint pain What should you tell your healthcare provider before taking Januvia

When you combine that with a GLP-1 receptor agonist like semaglutide , the theoretical rationale starts to make sense

As with any observational analysis of self-selected app users, some degree of selection bias may be present

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NICE advises against using opioids or gabapentinoids for chronic primary pain

A similar dual-target approach is seen in Zepbound, though the latter targets GLP-1 and GIP instead