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Holman RR, Bethel MA, Mentz RJ, Thompson VP, Lokhnygina Y, Buse JB, Chan JC, Choi J, Gustavson SM, Iqbal N, Maggioni AP, Marso SP, Ohman P, Pagidipati NJ, Poulter N, Ramachandran A, Zinman B, Hernandez AF, EXSCEL Study Group

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Vascular Protection Investigations in vascular calcification models showed: Attenuation of vascular smooth muscle calcification via AMPK activation Reduced expression of osteogenic markers in vascular tissue Protection against secondary myocardial remodeling Prevention of age-related vascular dysfunction Aging and Longevity Research Cellular Aging and Senescence Research examining MOTS-c in aging models revealed: Plasma MOTS-c levels decline approximately 21% between ages 18-30 and 70-81 years in humans Treatment delayed age-related functional decline in multiple mouse organ systems Improved stress resilience in aged mesenchymal stem cells Enhanced mitochondrial homeostasis in aged tissues Studies correlating endogenous MOTS-c levels with aging biomarkers suggest its decline contributes to age-related metabolic deterioration

Patients who are not diabetic but need weight management assistance