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It's harder to put hormones on the receptor, and so that's what happens with insulin [00:10:00] resistance

A global retrospective cohort study utilizing data from the TriNetX global network similarly reported a significant association between GLP-1RAs treatment and a lower AF and arrhythmias risk in individuals with obesity and without T2DM [30]

Clinicians often debate the principal pathogenic mechanisms, but no unifying theory has yet emerged

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While the combination therapy did not outperform the placebo, GLP-1 on its own showed a statistically significant improvement in liver scarring without worsening underlying liver inflammation, even among patients with the most advanced disease

AGA Clinical Practice Guideline on Pharmacological Interventions for Adults With Obesity