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Musculoskeletal effects, including joint discomfort, are referenced in published GLP-1 class safety data more broadly

Individuals were also ineligible if they had any contraindications to study treatment or if, in the opinion of the investigator, they had any other medical condition, clinically significant laboratory result or electrocardiogram findings that may compromise safety or compliance, preclude the participant from successful study completion or interfere with interpretation of results

In studies, gastrointestinal side effects were more common in people taking Zepbound than people taking placebo, and people taking Zepbound were more likely than those on placebo to stop treatment because of these side effects

Overall, our results align with other post hoc analyses with tirzepatide, which showed a greater clinical benefit, greater improvements in HbA1c and other cardiometabolic measures, with greater weight loss [41, 54]

Alcohol should also be approached with cautionit can worsen nausea and dehydration, both common during the first weeks of treatment