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[7] The US Food and Drug Administration (FDA) approved dulaglutide with a Risk Evaluation and Mitigation Strategy (REMS), [7] and granted the approval of Trulicity to Eli Lilly and Company

This is considered off-label but can be safer and more effective than dropping too low

Acute Kidney Injury Acute kidney injury occurred in clinical trials for weight reduction in 7 adult patients (0.4 cases per 100 patient years) receiving WEGOVY versus 4 patients (0.2 cases per 100 patient years of exposure) receiving placebo

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In other words, we achieved a number needed to harm (NNH) as high as 1537 patients

What are the signs I should stop semaglutide if I'm on methotrexate
