glp 1 kaiser coverage glp-1 permanente π Starting January 1, 2025, Kaiser Permanente will be making adjustments to the of GLP-1 drugs and other Anti-Obesity Medications (AOMs) in California commercial Nutritional priorities to support GLP-1
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However, potential adverse mental health effects have also been reported and require vigilance: Nausea and gastrointestinal symptoms , common side effects of GLP-1 medications, may increase anxiety in susceptible individuals Rapid weight loss can occasionally trigger psychological distress or exacerbate eating disorder behaviours Mood changes , including low mood, have been reported in post-marketing surveillance, though causality remains uncertain Some patients report feeling emotionally flat or detached , though this is anecdotal and not well characterised in clinical trials The Summary of Product Characteristics (SmPC) for GLP-1 receptor agonists used for weight management (such as Saxenda and Wegovy) includes specific warnings about monitoring for mood disorders and suicidal thoughts

In the 72-week SURMOUNT-1 trial summarised in Mounjaros Australian product information, average weight change ranged from -16.0% to -22.5% depending on dose, versus -2.4% with placebo
GLP-1 stimulates cell proliferation in pancreatic ductal cells and islets, and exerts antiapoptotic actions on islet -cells and neurons