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Perioperative use of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors for diabetes mellitus

Dehydration can lead to acute kidney injury, particularly in patients with pre-existing kidney disease or those taking certain medications

The slowed gastric emptying combined with altered gut motility creates unpredictable effects on colonic transit

It is a starting dose, not a treatment dose

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Additionally, gastrointestinal side effects are most pronounced during the first two weeks at a new dose and typically improve by weeks three and four