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Establishing a systematic incretin contactome atlas using super-resolution imaging and single-cell spatial omics will be vital to bridging these gaps and informing the design of next-generation therapies capable of precisely restoring intracellular structural and functional integrity ( A further layer of complexity is that MERCS remodeling is unlikely to follow a uniform, linear trajectory across tissues and disease stages

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Managing insulin resistance through lifestyle changes, reducing inflammation, and getting regular movement all contribute to better overall metabolic health and stronger GLP-1 signaling

It inhibits the SGLT2 protein

Data extraction From the included studies, key data were extracted, including the first author, publication year, NCT number, patient demographics (age, weight, BMI, waist circumference), sample size, treatment comparisons, and treatment durations