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When evaluating whether semaglutide might be contributing to leg cramps in an individual patient, clinicians must consider the temporal relationship between medication initiation or dose escalation and symptom onset, the presence of alternative explanations, and whether symptoms resolve with dose adjustment or discontinuation
EMA Decision P/0336/2024 Paediatric Investigation Plan: Retatrutide

Blood pressure normalizing from 145/95 to 120/78

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It manages appetite, stabilizes blood sugar, and aids in healthy fat reduction