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OASIS 4 involved a 64-week treatment period, including a 12-week dose escalation period and a 7-week off-treatment follow-up period

Unlike other GLP-1 agonists, Retatrutide targets GLP-1, GIP, and GCG receptors, making it a "triple G" or GGG tri-agonist

If you're asking, "how does Wegovy work," it primarily enhances insulin secretion and reduces appetite, aiding significant weight loss

Altogether, when administering GLP-1RA plus SGLT2i combination therapy, it is important to adopt an individualized approach to therapy taking into account individual preferences, costs and coverage, toxicity profile, consideration of kidney function and glucose-lowering efficacy, desire for weight loss, and comorbidities

Spread intake across meals: Research suggests that distributing protein across three to four meals per day aiming for roughly 2040 g per meal, depending on your total daily target is more effective for muscle protein synthesis than consuming the majority in one sitting

This effect is dose-dependent, with appetite suppression often increasing during dose titration (usually starting at 0.25mg weekly, then increasing to 0.5mg or 1mg)