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Tirzepatide has dose-dependent adverse effects

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Other signs to look out for include: Persistent vomiting or an inability to keep fluids down Signs of dehydration like dizziness, dark urine, or reduced urination Severe constipation or no bowel movements for several days Pain accompanied by fever, repeated vomiting, or signs of an abdominal infection Stomach pain that begins after a recent dose increase and doesnt improve Any symptoms that feel unusual or concerning to you A clinician can help determine whether what youre feeling is a normal part of the adjustment period, whether a dose change might help, or whether something else might be contributing to the pain

Seek immediate medical attention for severe or persistent abdominal pain (especially if radiating to the back), persistent vomiting, inability to keep fluids down, signs of dehydration, yellowing of skin/eyes, or fever, as these may indicate serious conditions like pancreatitis or gallbladder disease

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and is President Elect of The Obesity Society and an Executive Board Member of the American Society for Nutrition Foundation