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Over time, some of these agents (in particular, GLP-1 agonists and SGLT2 inhibitors), which were initially developed for their glucose-lowering actions, have demonstrated significant beneficial pleiotropic effects, thus expanding their potential therapeutic applications
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Hunt B, Malkin SJP, Moes RGJ, et al

16 Insulin receptors are distributed throughout the brain, but have the highest concentration in the olfactory bulb, cerebral cortex, hypothalamus, hippocampus, and cerebellum

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