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HbA1c Reductions GLP-1 medications produce substantial reductions in HbA1c (the measure of average blood sugar over 2-3 months): Semaglutide: Average HbA1c reduction of 1.5-1.8 percentage points in clinical trials

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Recommendations for the peri-operative management of patients taking glucagon-like peptide-1 receptor agonists and glucose-dependent insulinotropic peptide [1] : The risk of pulmonary aspiration and mitigation strategies should be discussed with the patient using a shared decision-making approach." "Patients should continue to take glucagon-like peptide-1 receptor agonists throughout the perioperative period." "Patients and clinicians should adhere to recommended fasting guidelines." "Upper gastrointestinal symptoms alone should not be used to determine gastric content." "Regional anaesthesia should be considered as the primary anaesthetic technique, if appropriate." "Point-of-care gastric ultrasound should be considered before induction of anaesthesia to facilitate risk stratification, if appropriate." "Individualised pulmonary aspiration risk assessment should be completed, accounting for drug, patient and procedural factors." "Anaesthesia and airway management should aim to reduce the risk of pulmonary aspiration on induction of anaesthesia, during maintenance and after emergence of anaesthesia

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Clarification, April 1, 4:15 pm ET: A previous version of this post referred to the semaglutide revolution. The story has been updated to clarify that not all the medications for weight loss discussed are semaglutides

While sulphonylureas potently promote insulin secretion in type-2 diabetic patients via inhibition of K ATP channel activity [[267], [268], [269], [270]], there is no clear evidence that sulphonylureas affect GLP-1 secretion in humans (as reviewed in [266])