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Weeks 5 to 12 (5 mg): Weight loss accelerates

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The body can no longer rely on the drug to reduce appetite, slowing the metabolism and causing the hunger hormone to kick back in, causing weight regain

Unfortunately, both have also been linked to severe side effects

Tirzepatide Dosage and Administration Tirzepatide treatment typically follows a gradual dose escalation to minimize potential side effects: Starting dose: 2.5 mg once weekly for 4 weeks Increase to 5 mg once weekly for at least 4 weeks If needed, further increases to 7.5 mg, 10 mg, or 12.5 mg once weekly, based on individual response and tolerability The medication is administered as a subcutaneous injection once a week