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Lifestyle modification and nutrition-based approaches are regarded as the cornerstone strategies for treating pediatric obesity

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These include dietary interventions, orlistat, lorcaserin, phentermine/topiramate, glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors, pramlintide, dapagliflozin, the duodenaljejunal bypass liner, gastric pacemakers and gastric balloons

Specifically, GLP-1 RAs showed significantly reduced risks of progression to systolic heart failure (HR 0.60) and stroke (HR 0.75) compared to SGLT2 inhibitors

This comprehensive review synthesizes current evidence on the mechanisms, established ...

Glucagon-like Peptide 1 Receptor Agonists and Obesity Associated with Eating Disorders