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Potential benefits In her own clinical practice, Ring has suggested berberine to her patients for years, as an additional therapy for managing conditions such as high cholesterol or insulin resistance, or for gastrointestinal issues, such as irritable bowel syndrome

The safety of RYBELSUS (formulation R2 - 1.5 mg, 4 mg and 9 mg strengths) [see Dosage and Administration (2.2)] and RYBELSUS (formulation R1 - 3 mg, 7, mg and 14 mg strengths) [see Dosage and Administration (2.3)] has been established as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus based on adequate and well-controlled studies of RYBELSUS (formulation R1) in adult patients with type 2 diabetes mellitus [see Clinical Pharmacology (12.3), Clinical Studies (14)]