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Description
At the start of the study, the median baseline body mass index among study participants was 38.5

It has no cardiac effects
Commonly reported adverse effects include: Gastrointestinal symptoms nausea, vomiting, diarrhoea, and constipation were the most frequently reported side effects, particularly during dose escalation
For example, VSG surgery enhances resting-state functional connectivity between the hippocampus and the insula [41] and between the dorsolateral PFC and the anterior cingulate, with these outcomes accompanied by dampened cravings for high calorie foods [42] and reduced fasting levels of ghrelin [41,42]

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Contrave is not recommended for people with uncontrolled high blood pressure, seizure disorders, or a history of eating disorders
