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5.4 Gastrointestinal Side Effects and Nutrient Loss Nausea and vomiting are well-documented adverse effects. Persistent vomiting or diarrhoea may: Increase electrolyte loss Reduce caloric intake Reduce dietary diversity However: These effects are typically transient and dose-related

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All retrieved articles were screened for relevance based on their discussion of factors influencing DR onset, progression and DME formation, the relationship between glycemic control and retinopathy outcomes in both short- and long-term contexts, and the association between glycemic improvement and early or transient worsening of DR

This flexibility allows for a broader range of individuals to access semaglutide treatment, particularly those who may struggle with obesity-related health issues