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In one trial, 638 patients randomized to 1 of 3 treatment arms following a 1-week lead-in period received: dapagliflozin 10 mg plus metformin HCl extended-release (up to 2,000 mg/day), dapagliflozin 10 mg plus placebo, or metformin HCl extended-release (up to 2,000 mg/day) plus placebo

In the phase 3 OASIS 4 trial, adults taking a 25 mg daily dose of oral semaglutide lost an average of 13.6% of their body weight, compared with a placebo

For weekly formulations like tirzepatide, discontinuation was typically advised at least one week before surgery, accounting for the medication's half-life of approximately 5 days

Data analyses and calculations were performed as previously described 48

Statistical methods A total of 111 participants were planned to be randomized so that 93 participants (31 per treatment group) would complete the study

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