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Once in circulation, GLP-1 exerts powerful metabolic effects: it enhances glucose-dependent insulin secretion from the pancreas, suppresses excess glucagon, and signals the hypothalamic nuclei in the brain to promote satiety

[ 18 F]FB(ePEG12)12-exendin-4 (0.148 MBq/mouse) was injected via the tail vein, and PET/CT imaging was performed after 30 min postinjection under 2.0% isoflurane anesthesia using a Triumph LabPET12/SPECT4/CT (TriFoil Imaging Inc., Chatsworth, CA, USA), as previously described 12

Congenital heart disease (CHD) and infective endocarditis (IE)

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Reserve osmotic laxatives like MiraLAX for breakthrough constipation, using them 2-3 times weekly at most