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The appetite suppression timeline differs between individuals based on genetics, metabolic rate, and yes, sublingual technique quality

doi: 10.1016/j.celrep.2020.107768 47 GutzwillerJ-PHruzPHuberARHamelCZehnderCDreweJet al

GI side effects are uniformly higher with retatrutide, reflecting the additional receptor stimulation
Theres even evidence to support that it may ease hormone-related symptoms like hot flashes, too

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Cardiovascular outcome trials show that treatment with long-acting GLP-1 medicines such as liraglutide, dulaglutide, and semaglutide reduces cardiovascular events in people living with T2D and with semaglutide also in people living with obesity (6062)
