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The most prominent metabolic alterations in HF are a reduction in the utilization of FAO and ATP production (5759)

The drug has not fully cleared, and receptors have not had adequate time to recover

The main adjustment comes from increased dietary fiber that supports healthy metabolism and digestive enzyme support

In Graves disease, where extrathyroidal manifestations are mediated by TSHR/IGF-1R-expressing fibroblasts, studies could test GLP-1RAs as adjuncts to antithyroid drugs or biologics (for example, alongside IGF-1R blockade for orbitopathy) to reduce systemic inflammation and metabolic drivers without compromising disease control [19,25,67]

In vitro studies suggest better biocompatibility compared to glucose, while clinical trials indicate its effectiveness as an osmotic agent and its potential to improve glycemic control in diabetic PD patients [147]
