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Other important safety considerations include injection site reactions, increased heart rate (a class effect, though potentially more pronounced with liraglutide), and risk of pancreatitis (which requires immediate discontinuation if suspected)

As shown in Table 2, the HFD-induced increases in body weight, liver index, fasting serum levels of glucose, ALT and AST were all significantly reduced by treatment with NaB

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In the kidney, GLP-1RAs directly induce natriuresis and diuresis by acting on the proximal convoluted tubule (PCT) through inhibition of sodium-hydrogen exchanger 3 (NHE3)