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Funch D, Mortimer K, Ziyadeh NJ, et al

The rooms were temperature (21.5 1.0 C) and humidity (57.8% 3.9%) controlled under a reversed day-night cycle (lights off at 8.00 photometry & 12.30 for food intake)

Hansen et al., 2021)

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So, typically the more effective the medication, the more likely the risk of adverse events