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Samantha Snashall, a registered dietitian at Ohio State Wexner Medical Center, warns: "Be careful if the volume on the food noise goes down so low while on a GLP-1 that you forget to eat three meals and a couple of snacks a day

Severe side effects of the medication are: Severe gastrointestinal problems Low blood sugar levels (hypoglycemia) Changes in vision due to diabetic retinopathy pancreatitis Gallbladder problems Hypoglycemia Allergic reaction to the medication Severe stomach pain Risk of aspiration during sedation or anesthesia Mood and behavioural changes Suicidal ideation Limitations Semaglutide is contraindicated for patients with a history or family history of thyroid cell tumors (MTC) and endocrine cancers (MEN 2 syndrome) because the medication increases the risk of these tumors in rodent studies

Once-weekly spacing between doses remains the foundation of semaglutide's proven efficacy

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PMCID: PMC8826179

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