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Mechanistically, testosterone still has a clear role in improving insulin sensitivity indirectly by promoting fat loss and muscle growth, both of which enhance the bodys ability to regulate blood sugar, says Lee

accepted January 7, 2026

The combination protocol increases the number of dose escalation events (since you are titrating two compounds), which may mean more frequent but generally mild headaches

& Pederson, R

The Wegovy pill contains semaglutide, which mimics a natural gut hormone called GLP-1

Temporary fatigue can occur initially, but most patients find that energy levels stabilize and often improve significantly as treatment continues