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Description
GLP-1s were originally developed as diabetes medications

This triple-action mechanism works by reducing appetite, slowing gastric emptying, improving insulin secretion, and increasing energy expenditure

People who understand this going in tend to have far better long-term outcomes than those expecting visible changes within the first two weeks

This drug class originated with the French Lilac

Uzoigwe, C., Liang, Y., Whitmire, S

The second trial included a broader array of antipsychotics, but liraglutide only showed nonsignificant trends toward lower weight and HbA1c, possibly because of a small sample size (47) (Whicher CA et al, Diabetes Obes Metab 2021;23(6):12621271)
