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Objective To determine whether the use of glucagon-like peptide-1 (GLP-1) receptor agonists is associated with an increased risk of suicidal ideation, self-harm, and suicide among patients with type 2 diabetes compared with the use of dipeptidyl peptidase-4 (DPP-4) inhibitors or sodium-glucose cotransporter-2 (SGLT-2) inhibitors

The GLP-1 receptor agonist market size was exhibited at USD 36.95 billion in 2023 and is projected to hit around USD 261.19 billion by 2033, growing at a CAGR of 21.6% during the forecast period 2024 to 2033.

Dual- and multi-receptor agonists may be a novel drug class to treat obesity and type 2 diabetes mellitus with high efficacy.

Injection-site reactions and worsening of pre-existing diabetic retinopathy are also relevant clinical concerns

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Interestingly, glucagon-like peptide-1 receptor agonists (GLP-1RAs), used in the treatment of T2DM and obesity, are known to show pro-cognitive and neuroprotective properties, and exert modulatory effects on immune, endocrine and metabolic processes in the central nervous system