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Description
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

Phase 3 can be the most difficult

Many patients find that titrating slowly (starting at the lowest dose and increasing gradually) reduces early reflux symptoms while maintaining weight loss results

doi: 10.1093/eurheartj/ehae613 41 WangWBainSCBianFChenRGaberySHuangSet al

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