glp-1 gonzales For many Medicare beneficiaries, access to medications for obesity has been limited by cost. Since the Medicare GLP-1 Bridge Program launched on July 1, our team has been actively helping… The Rise of GLP-1 Medications

Diabetes Res Clin Pract 162:108072

In 2015, obesity was estimated to have accounted for four million deaths globally, two-thirds of which were caused by CVD

Our joint efforts led to the development of GLP-1 analogs for diabetes and obesity

When GLP-1 binds to its receptor, it amplifies the insulin signaling pathway, causing increased phosphorylation of insulin receptor substrates and activating the PI3K/Akt pathway, which ultimately results in enhanced glucose uptake, utilization within the liver, and reduced production of glucose (gluconeogenesis)

Zepbound (tirzepatide) was studied in adults up to age 75 in major clinical trials, and safety data show that advancing age is not a contraindication to GLP-1 therapy

It is a mitochondrial modulator