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The base effect: why expected widening amplifies the signal A third of the savings made on food by users of GLP-1 medications are being redirected to other health and wellness categories (clothing, wellness products), according to analysts cited by LinkedIn

In some cases, it can get worse if blood sugar improves too quickly

2020;16(Suppl 9):e042909

French physiologist Jean La Barre first used the term incretine in 1932 to describe a substance which lowered glucose levels by augmenting insulin release and actions.4 5 We now know that GLP-1 and glucose-dependent insulinotropic peptide (GIP) are the two main incretin hormones

In select cases, probiotics may be incorporated into a routine to support digestive comfort as the gut adapts to new intake patterns, though individual response can vary

Conclusions Evidence accrued so far suggest that GLP-1RA could exert a modest renal benefit alongside CV protection, justifying its place as second-line drug in patients with T2D and CKD not achieving glycemic control with SGLT-2i and metformin according to KDIGO guidelines [87]