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Interestingly, while Ex4 did not alter saccharin intake during heroin access, a history of Ex4 treatment enhanced saccharin acceptance during extinction trials, suggesting mitigation of heroin-induced devaluation of natural reward

These heritable molecular alterations regulate gene expression patterns and influence key pathophysiological processes, including ovarian dysfunction, hormonal dysregulation, and insulin signaling impairment, without modifying the underlying DNA sequence (48, 49)

Combination therapy with once-weekly glucagon like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes: a case series

doi:10.1016/S0140-6736(09)60659-0 90

2023;14 doi: 10.3389/FENDO.2023.1085799
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