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Description
The underlying reason is that, in the case of parenteral presentations, the effective doses of GLT-1 receptor agonists necessary for weight control are greater than those needed for glycemic control

Among the Eli Lilly trials is one for orforglipron (LY3502970), a novel, oral non-peptide GLP-1 RA, which is the subject of four trials in the clinicaltrials.gov data

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doi: 10.1073/pnas.80.14.4546

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These agents act on multiple metabolic pathways, improving insulin sensitivity, reducing body weight, and lowering systemic inflammation, all of which contribute to nerve damage in diabetes
