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Development: Martin Holst Lange, EVP for Development (now Chief Scientific Officer as of Aug 2025), leads R&D critical for Novos future pipeline

The Science What to Expect During the Treatment Process For those who are new to the idea of semaglutide weight loss injections, understanding the treatment process can ease any concerns you might have

Most participants approach weight loss plateau around weeks 40-48, though clinical trial data showed participants were still losing weight at study conclusion, suggesting even longer treatment courses might yield additional benefits

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Briefly, the construct was produced by stable expression and secretion from CHO-K1 cells and then purified by a sequential combination of 9E10 antibody-affinity chromatography and size-exclusion chromatography as previously described 35 , with the final sample being prepared at a concentration of 0.2 mg mL 1 in a 24.8 mM Tris-HCl (pH 8.0), 137 mM NaCl, 2.7 mM KCl plus 0.02% NaN 3 (TBSA)

One side effect Ive observed with tirzepatide that I have not seen with semaglutide: allodynia, a heightened skin sensitivity where normal touch feels uncomfortable or painful