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Evaluation of GIP and Intestinal GLP-1 (7-36) Amide Function in Hyperphagic States

In addition, Ex-4 provides neuroprotection against ischemia-induced damage in the hippocampus by downregulating hypoxia-inducible factor-1 and modulating apoptosis through the increased B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X-protein (Bax) ratio, which is mediated by the GLP-1 receptor [48]
Among the exendin 939 fragments, exendin 2029 specifically binds to TRPV1, alleviating pain in both acute and chronic pain models without interfering with GLP-1R function

In addition, ghrelin was reported to exert a prokinetic effect on the small bowel, where it stimulates activity front of the migrating motor complex (MMC) through cholinergic mechanisms (26)

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