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I suspect this improvement is multifactorial because diabetic patients feel better overall once their blood sugar is more adequately controlled, and obese patients find improved musculoskeletal symptoms and body image thoughts as they lose weight on these medications

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The glucagon receptor agonism component directly promotes hepatic lipid oxidation and reduces de novo lipogenesis, providing fat reduction that extends beyond what would be expected from weight loss alone

Diarrhoea is reported in around 30% of users across the STEP trials

GLP-1 agonists slow down gastric emptying which could potentially impact the amount of oral medication absorbed by the body.

Respondents with PCOS were even more likely to report changes (43%), with the most common being more predictable, more frequent, or shorter periods