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Nature 494, 256260

Two insulin:GLP-1 co-formulated combinations have been approved to treat T2D: lixisenatide-insulin glargine and liraglutide-insulin degludec

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Other clinically developed small-molecule GcgR antagonists include PF-06291874, LY2409021, and LGD-6972 (RVT-1502), all of which have advanced to clinical trials but ultimately were not pursued further for the treatment of T2D or obesity due to the associated increases in circulating LDL-C, body weight, hepatic fat, and blood pressure [31]

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Side effects were qualitatively similar with semaglutide, as expected: nausea (52% of patients), diarrhea (27%) and vomiting (24%) being a few of the most common