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Description
[1] Important safety considerations include the risk of hypoglycaemia when combined with insulin or sulfonylureas, potential dehydration and acute kidney injury with severe gastrointestinal symptoms, and for semaglutide specifically, possible worsening of diabetic retinopathy in those with pre-existing disease
In particular, in a RCT in women with PCOS with BMI 25 kg/m 2 and/or insulin resistance, Frssing et al

UK dispatched
[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Beddows C.A., Shi F., Horton A.L., Dalal S., Zhang P., Ling C.-C., Yong V.W., Loh K., Cho E., Karagiannis C., et al

Mitochondrial assay solution (MAS, 1) contains 220 mM mannitol, 70 mM sucrose, 5 mM MgCl 2 , 10 mM KH 2 PO 4 , 2 mM HEPES, 1 mM EGTA, and 0.2% (w/v) fatty acid-free BSA, pH 7.2 at 37 C

Our dose-response data showed it escalating from ~3% at 1mg to ~25% at 12mg, which matched the Phase 3 TRIUMPH-4 finding (20.9% at 12mg) -- one of the clearest validations of Reddit data against clinical trial results
