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Tirzepatide, at all doses, had higher risks of AE-related discontinuation than insulin

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GLP-1 RA use was consistently associated with improvements in headache frequency, weight reduction, and reduced need for acetazolamide or surgical interventions

However, no retrospective epidemiological studies can provide definitive answers, and nausea, vomiting and diarrhoea remain the most clinically relevant adverse effects of these drugs, compromising long-term adherence.

exploratory improvements reported in waist circumference, HbA1c, lipids, and CRP in secondary summaries