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D.PoriesW.FahrbachK.et al (2004)

The six most common causes of GLP-1 fatigue are: Eating too few calories Low protein intake and muscle loss Dehydration and low electrolytes Metabolic adaptation and energy conservation Blood sugar fluctuations Poor sleep quality (often compounded by under-eating) Cause 1: Eating Too Few Calories This is the most common driver of fatigue in GLP-1 users

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For type 2 diabetes, the SURPASS trials demonstrated robust HbA1c reductions of 1.9-2.4 percentage points