pros and cons of glp 1 drugs 🎉A new approach to weight loss! 🎉 GLP-1 medications are changing the landscape weight management. Join us for FREE classes to learn more about these medicines. ➡️This week's class: ⏰SATURDAY MAR Mapping the effectiveness and risks

The magnitude of the benefits of GLP-1RA and SGLT-2 inhibitors on MACE are similar, ranging from 12 to 14% reduction of risk, but only GLP-1RA may reduce the risk of stroke

In randomized clinical trials, semaglutide-treated patients with obesity lost twice as much weight as other GLP-1R agonists (Ahmann et al., 2018

Diab Vasc Dis Res 8(2):117124 Yue W, Li Y, Ou D, Yang Q (2019) The GLP-1 receptor agonist liraglutide protects against oxidized LDL-induced endothelial inflammation and dysfunction via KLF2

The cardiorenal effects of both GLP-1RA and SGLT-2 inhibitors can be summarized as follows: GLP-1RA have moderate benefits on MACE (major cardiovascular events), may reduce all-cause mortality and hospitalization for HF (HHF), and have a robust effect in reducing the incidence of macroalbuminuria [12]

8 Given the individual and population health impact, it is our position that obesity should be addressed as proactively as other chronic conditions, with an evidence-based approach that can drive optimal health outcomes

Moreover, the elevated markers of oxidative stress precede A deposition and NFTs, suggesting that oxidative stress is an early event in the pathogenesis of AD (67)